L-364,373
Product Specifications
UNSPSC Description
L-364,373 (R-L3) is a voltage-gated Kv7.1 (KCNQ1)/mink channels activator. L-364,373 activates Iks (slow delayed rectifier potassium current) and shortens action potential duration in guinea pig cardiac myocytes, and suppresses early afterdepolarizations in rabbit ventricular myocytes[1].
Target Antigen
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/l-364-373.html
Purity
99.67
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N(C)C2=CC=CC=C2C(C3=CC=CC=C3F)=N[C@@H]1CC4=CNC5=C4C=CC=C5
Molecular Weight
397.44
References & Citations
[1]Jow F, et al. Rb+ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373). Assay Drug Dev Technol. 2006 Aug;4(4):443-50.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-108591/L-364-373-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-108591/L-364-373-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
103342-82-1
Available Sizes
Curated Selection
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