L-364,373

L-364,373 (R-L3) is a voltage-gated Kv7.1 (KCNQ1) /mink channels activator. L-364,373 activates Iks (slow delayed rectifier potassium current) and shortens action potential duration in guinea pig cardiac myocytes, and suppresses early afterdepolarizations in rabbit ventricular myocytes[1].

Product Specifications

CAS Number

[103342-82-1]

Product Name Alternative

R-L3

UNSPSC

12352005

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/l-364-373.html

Purity

99.65

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1N(C)C2=CC=CC=C2C(C3=CC=CC=C3F)=N[C@@H]1CC4=CNC5=C4C=CC=C5

Molecular Formula

C25H20FN3O

Molecular Weight

397.44

References & Citations

[1]Jow F, et al. Rb+ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373) . Assay Drug Dev Technol. 2006 Aug;4 (4) :443-50.