(S) -Rasagiline

(S) -Rasagiline (TVP1022) is the relatively inactive S-enantiomer form of Rasagiline. Rasagiline is a highly potent selective irreversible MAO inhibitor with IC50s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively[1]. (S) -Rasagiline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[185517-74-2]

Product Name Alternative

TVP1022; S-PAI

UNSPSC

12352005

Hazard Statement

H302, H400

Target

Monoamine Oxidase

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/TVP1022.html

Purity

99.80

Solubility

DMSO : 100 mg/mL (ultrasonic) |Ethanol : 100 mg/mL (ultrasonic)

Smiles

C#CCN[C@H]1CCC2=CC=CC=C21

Molecular Formula

C12H13N

Molecular Weight

171.24

Precautions

H302, H400

References & Citations

[1]M B Youdim, et al. Rasagiline [N-propargyl-1R (+) -aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B. Br J Pharmacol. 2001 Jan;132 (2) :500-6.