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Pazopanib (Hydrochloride) (Standard)

Pazopanib (Hydrochloride) (Standard) is the analytical standard of Pazopanib (Hydrochloride) . This product is intended for research and analytical applications. Pazopanib Hydrochloride (GW786034 Hydrochloride) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with an IC50 of 10, 30, 47, 84, 74, 140 and 146 nM, respectively.

Product Specifications

CAS Number

635702-64-6

Product Name Alternative

GW786034 (Hydrochloride) (Standard)

UNSPSC

12352005

Target

Autophagy; c-Fms; c-Kit; FGFR; PDGFR; Reference Standards; VEGFR

Type

Reference compound

Related Pathways

Autophagy; Others; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pazopanib-hydrochloride-standard.html

Smiles

CC1=CC=C(C=C1S(N)(=O)=O)NC2=NC=CC(N(C3=CC4=NN(C(C)=C4C=C3)C)C)=N2.Cl

Molecular Formula

C21H24ClN7O2S

Molecular Weight

473.98

References & Citations

[1]Harris PA, et al. Discovery of 5-[[4-[ (2,3-dimethyl-2H-indazol-6-yl) methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor. J Med Chem. 2008, 51 (15), 4632-4640.|[2]Thakur A, et al. Pazopanib, a multitargeted tyrosine kinase inhibitor, reduces diabetic retinal vascular leukostasis and leakage. Microvasc Res. 2011 Nov;82 (3) :346-50.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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