N- (3-Oxohexanoyl) -L-homoserine lactone

N- (3-Oxohexanoyl) -L-homoserine lactone (OHHL; N- (3-Oxohexanoyl) homoserine lactone) is a specific agonist of LuxR-type transcription factor CarR with a Kd of 1.8 μM. N- (3-Oxohexanoyl) -L-homoserine lactone activates CarR by inducing protein multimerization, promoting its binding to target DNA sequences in the carR-carA intergenic region, thereby upregulating the transcription of carbapenem biosynthesis genes. N- (3-Oxohexanoyl) -L-homoserine lactone acts as a quorum sensing signal molecule, enabling bacteria to coordinate the production of carbapenem antibiotics in a cell density-dependent manner. N- (3-Oxohexanoyl) -L-homoserine lactone is used to study bacterial quorum sensing mechanisms, especially the secondary metabolism and virulence factor regulatory pathways of Erwinia carotovora and Yersinia enterocolitica[1][2][3].