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ZM-32

ZM-32 is an inhibitor for human antigen R (HuR), that downregulates the expression of VEGF-A and MMP9, and thus inhibits breast cancer tumor angiogenesis. ZM-32 exhibits broad-spectrum anti-proliferative effects in a variety of cancer cell lines, and exhibits antitumor efficacy against MDA-MB-231 in mouse models[1].

Product Specifications

CAS Number

2667585-44-4

UNSPSC

12352005

Target

HuR; MMP

Type

Reference compound

Related Pathways

Epigenetics; Metabolic Enzyme/Protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/zm-32.html

Smiles

O=C(NCC1CC(CCCCCCCCCCCC1)=O)C2=CC=C(C=C2)OC

Molecular Formula

C24H37NO3

Molecular Weight

387.56

References & Citations

[1]Yang LQ, et al., Muscone derivative ZM-32 inhibits breast tumor angiogenesis by suppressing HuR-mediated VEGF and MMP9 expression. Biomed Pharmacother. 2021 Apr;136:111265.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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