Kamebakaurin

Kamebakaurin is an orally active diterpenoid compound that can be isolated from Isodon excia (Maxin.) . Kamebakaurin can inhibit NF-κB activation by directly targeting the DNA-binding activity of p50. Kamebakaurin can induce apoptosis and cell cycle arrest in tumor cells. Kamebakaurin has anti-inflammatory and anti-tumor activities[1][2][3].

Product Specifications

CAS Number

[73981-34-7]

UNSPSC

12352211

Target

Apoptosis; Caspase; HIF/HIF Prolyl-Hydroxylase; NF-κB

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/kamebakaurin.html

Purity

98.36

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@@]23[C@](CC[C@@]1([H])C(C3=O)=C)([H])[C@]4([C@](C(C)(CC[C@@H]4O)C)([H])C[C@H]2O)CO

Molecular Formula

C20H30O5

Molecular Weight

350.45

References & Citations

[1]Lee JH, et al. Kaurane diterpene, kamebakaurin, inhibits NF-kappa B by directly targeting the DNA-binding activity of p50 and blocks the expression of antiapoptotic NF-kappa B target genes. J Biol Chem. 2002 May 24;277 (21) :18411-20.|[2]Yoshioka H, et al. Suppressive effect of kamebakaurin on acetaminophen-induced hepatotoxicity by inhibiting lipid peroxidation and inflammatory response in mice. Pharmacol Rep. 2017 Oct;69 (5) :903-907.|[3]Wang KS, et al. Kamebakaurin inhibits the expression of hypoxia-inducible factor-1α and its target genes to confer antitumor activity. Oncol Rep. 2016 Apr;35 (4) :2045-52.