Cediranib (maleate)
Product Specifications
Product Name Alternative
AZD-2171 maleate
UNSPSC Description
Cediranib maleate (AZD-2171 maleate) is a highly potent, orally available VEGFR inhibitor with IC50s of <1, <3, 5, 5, 36, 2 nM for Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit, respectively.
Target Antigen
Autophagy; PDGFR; VEGFR
Type
Reference compound
Related Pathways
Autophagy;Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Cediranib-maleate.html
Purity
99.95
Solubility
DMSO : ≥ 45 mg/mL|H2O : 2 mg/mL (ultrasonic)
Smiles
O=C(O)/C=C\C(O)=O.FC1=C(OC2=C(C(C=C3OCCCN4CCCC4)=NC=N2)C=C3OC)C=CC5=C1C=C(C)N5
Molecular Weight
566.58
References & Citations
[1]Wedge SR, et al. AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res, 2005, 65(10), 4389-4400.Life Sci. 2024 Jun 23:122862.|Biomaterials. 2018 Apr;161:164-178. |Biomed Res Int. 2021 Mar 30.|Cell Stem Cell. 2019 Sep 5;25(3):373-387.e9.|Eur J Pharmacol. 2023 Dec 27:176278.|Harvard Medical School LINCS LIBRARY|J Med Chem. 2023 Dec 13.|Neuro Oncol. 2016 Apr;18(4):538-48. |Sci Signal. 2015 Dec 8;8(406):ra125. |Sci Transl Med. 2018 Jul 18;10(450):eaaq1093.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-13049/Cediranib-maleate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-13049/Cediranib-maleate-SDS-MedChemExpress.pdf
Clinical Information
Phase 3
CAS Number
857036-77-2
Available Sizes
Curated Selection
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