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Cediranib (maleate)

Cediranib maleate (AZD-2171 maleate) is a highly potent, orally available VEGFR inhibitor with IC50s of <1, <3, 5, 5, 36, 2 nM for Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit, respectively.

Product Specifications

CAS Number

[857036-77-2]

Product Name Alternative

AZD-2171 maleate

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; PDGFR; VEGFR

Type

Reference compound

Related Pathways

Autophagy; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Cediranib-maleate.html

Concentration

10mM

Purity

99.95

Solubility

DMSO : ≥ 45 mg/mL|H2O : 2 mg/mL (ultrasonic)

Smiles

O=C(O)/C=C\C(O)=O.FC1=C(OC2=C(C(C=C3OCCCN4CCCC4)=NC=N2)C=C3OC)C=CC5=C1C=C(C)N5

Molecular Formula

C29H31FN4O7

Molecular Weight

566.58

Precautions

H302, H315, H319, H335

References & Citations

[1]Wedge SR, et al. AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res, 2005, 65 (10), 4389-4400.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 3

Isoform

PDGFRα; PDGFRβ; VEGFR1/Flt-1; VEGFR2/KDR/Flk-1; VEGFR3/Flt-4

Citation 01

Life Sci. 2024 Jun 23:122862.|Biomaterials. 2018 Apr;161:164-178. |Biomed Res Int. 2021 Mar 29:2021:5582648.|Cell Stem Cell. 2019 Sep 5;25 (3) :373-387.e9.|Discov Oncol. 2024 Nov 19;15 (1) :678.|Eur J Pharmacol. 2024 Feb 5:964:176278.|Harvard Medical School LINCS LIBRARY|J Med Chem. 2023 Dec 28;66 (24) :16597-16614.|Neuro Oncol. 2016 Apr;18 (4) :538-48. |Sci Signal. 2015 Dec 8;8 (406) :ra125. |Sci Transl Med. 2018 Jul 18;10 (450) :eaaq1093.

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