Cediranib (maleate)
Cediranib maleate (AZD-2171 maleate) is a highly potent, orally available VEGFR inhibitor with IC50s of <1, <3, 5, 5, 36, 2 nM for Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit, respectively.
Product Specifications
CAS Number
[857036-77-2]
Product Name Alternative
AZD-2171 maleate
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; PDGFR; VEGFR
Type
Reference compound
Related Pathways
Autophagy; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Cediranib-maleate.html
Concentration
10mM
Purity
99.95
Solubility
DMSO : ≥ 45 mg/mL|H2O : 2 mg/mL (ultrasonic)
Smiles
O=C(O)/C=C\C(O)=O.FC1=C(OC2=C(C(C=C3OCCCN4CCCC4)=NC=N2)C=C3OC)C=CC5=C1C=C(C)N5
Molecular Formula
C29H31FN4O7
Molecular Weight
566.58
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
PDGFRα; PDGFRβ; VEGFR1/Flt-1; VEGFR2/KDR/Flk-1; VEGFR3/Flt-4
Citation 01
Available Sizes
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