ABC99

ABC99 is an N-hydroxyhydantoin (NHH) carbamate that selectively inhibits the Wnt-deacylating enzyme NOTUM (IC50=13 nM) . ABC99 preserves Wnt3A signaling in the presence of NOTUM[1].

Product Specifications

CAS Number

2331255-53-7

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Wnt

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/abc99.html

Concentration

10mM

Purity

98.48

Solubility

DMSO : 25 mg/mL (ultrasonic; heat to 80°C)

Smiles

O=C(N1C2=CC=CC=C2OCC1)ON(C3=O)C(N4C3CN(CC5=CC=C(Cl)C=C5)CC4)=O

Molecular Formula

C22H21ClN4O5

Molecular Weight

456.88

Precautions

H302, H315, H319

References & Citations

[1]Suciu RM, et al. Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling. ACS Med Chem Lett. 2018;9 (6) :563-568.