Antipyrine-d3

Antipyrine-d3 is the deuterium labeled Antipyrine. Antipyrine (Phenazone) is an antipyretic and analgesic. Antipyrine can be used as a probe agent for oxidative agent metabolism. Antipyrine has been widely used in assessment of hepatic oxidative capacity[1][2].

Product Specifications

CAS Number

[65566-62-3]

Product Name Alternative

Phenazone-d3; Phenazon-d3

UNSPSC

12352005

Hazard Statement

H302

Target

Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Others

Field of Research

Inflammation/Immunology

Purity

99.91

Solubility

10 mM in DMSO

Smiles

O=C(C=C1C)N(C2=CC=CC=C2)N1C([2H])([2H])[2H]

Molecular Formula

C11H9D3N2O

Molecular Weight

191.24

Precautions

H302

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Stevenson, I.H., Factors influencing antipyrine elimination. Br J Clin Pharmacol, 1977. 4 (3) : p. 261-5.|[3]Engel G, et, al. Antipyrine as a probe for human oxidative drug metabolism: identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation. Clin Pharmacol Ther. 1996 Jun;59 (6) :613-23.