Ligustrazine

Ligustrazine (Chuanxiongzine), an alkylpyrazine isolated from Ligusticum chuanxiong Hort. (Chuan Xiong) [1], is present in french fries, bread, cooked meats, tea, cocoa, coffee, beer, spirits, peanuts, filberts, dairy products and soy products as fragrance and flavouring ingredienexhibits. Ligustrazine also has potential nootropic and anti-inflammatory activities in rats[2][3].

Product Specifications

CAS Number

[1124-11-4]

Product Name Alternative

Chuanxiongzine; Tetramethylpyrazine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis

Type

Natural Products

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Tetramethylpyrazine.html

Purity

99.99

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC1=C(C)N=C(C)C(C)=N1

Molecular Formula

C8H12N2

Molecular Weight

136.20

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhao Y, et al. Mechanisms and Clinical Application of Tetramethylpyrazine (an Interesting Natural Compound Isolated from Ligusticum Wallichii) : Current Status and Perspective. Oxid Med Cell Longev. 2016;2016:2124638.|[2]Wu W, et al. Tetramethylpyrazine protects against scopolamine-induced memory impairments in rats by reversing the cAMP/PKA/CREB pathway. Behav Brain Res. 2013 Sep 15;253:212-6.|[3]Kao TK, et al. Tetramethylpyrazine reduces cellular inflammatory response following permanent focal cerebral ischemia in rats. Exp Neurol. 2013 Sep;247:188-201.