Bromoacetamido-PEG4-acid
Bromoacetamido-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bromoacetamido-PEG4-acid is also a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [2].
Product Specifications
CAS Number
1807518-67-7
UNSPSC
12352203
Hazard Statement
H315, H318, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bromoacetamido-peg4-acid.html
Purity
97.0
Solubility
10 mM in DMSO
Smiles
O=C(O)CCOCCOCCOCCOCCNC(CBr)=O
Molecular Formula
C13H24BrNO7
Molecular Weight
386.24
Precautions
H315, H318, H335
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.|[2]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker; PEG Linkers
Available Sizes
Frequently Asked Questions
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