Bromoacetamido-PEG4-acid

Bromoacetamido-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bromoacetamido-PEG4-acid is also a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [2].

Product Specifications

CAS Number

[1807518-67-7]

UNSPSC

12352203

Hazard Statement

H315, H318, H335

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bromoacetamido-peg4-acid.html

Purity

97.0

Solubility

10 mM in DMSO

Smiles

O=C(O)CCOCCOCCOCCOCCNC(CBr)=O

Molecular Formula

C13H24BrNO7

Molecular Weight

386.24

Precautions

H315, H318, H335

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.|[2]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.