Dinaciclib
Dinaciclib (SCH 727965) is a potent inhibitor of CDK, with IC50s of 1 nM, 1 nM, 3 nM, and 4 nM for CDK2, CDK5, CDK1, and CDK9, respectively[1].
Product Specifications
CAS Number
[779353-01-4]
Product Name Alternative
SCH 727965
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; CDK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Dinaciclib.html
Purity
99.80
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OCC[C@H]1N(CCCC1)C2=NC3=C(C=NN3C(NCC4=C[N+]([O-])=CC=C4)=C2)CC
Molecular Formula
C21H28N6O2
Molecular Weight
396.49
Precautions
H302, H315, H319, H335
References & Citations
[1]Parry D, et al.
 Dinaciclib (SCH 727965), a novel and potent cyclin-dependent kinase inhibitor.
 Mol Cancer Ther. 2010 Aug;9 (8) :2344-53.|[2]Feldmann G, et al. Cyclin-dependent kinase inhibitor Dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft models. Cancer Biol Ther. 2011 Oct 1;12 (7) :598-609.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
CDK1; CDK2; CDK5; CDK9
Available Sizes
Curated Selection
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