CDK2-IN-4

CDK2-IN-4 (compound 73) is a potent and selective CDK2 inhibitor with an IC50 of 44 nM for CDK2/cyclin A, shows 2,000-fold selectivity over CDK1/cyclin B (IC50=86 uM) [1].

Product Specifications

CAS Number

[2079895-42-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cdk2-in-4.html

Purity

99.85

Solubility

DMSO : 20.83 mg/mL (ultrasonic)

Smiles

O=S(C1=CC=C(C=C1)NC2=NC3=NC=NC3=C(C4=CC(C5=CC=CC=C5)=CC=C4)N2)(N)=O

Molecular Formula

C23H18N6O2S

Molecular Weight

442.49

Precautions

H302, H315, H319, H335

References & Citations

[1]Coxon CR, et al. Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines. J Med Chem. 2017 Mar 9;60 (5) :1746-1767.