Zanubrutinib (Standard)
Zanubrutinib (Standard) is the analytical standard of Zanubrutinib. This product is intended for research and analytical applications. Zanubrutinib (BGB-3111) is a selective and orally active Bruton tyrosine kinase (Btk) inhibitor (IC50: 0.3 nM) [1][2].
Product Specifications
CAS Number
1691249-45-2
Product Name Alternative
BGB-3111 (Standard)
UNSPSC
12352005
Hazard Statement
H301, H311, H331, H341
Target
Btk; Reference Standards
Type
Reference Standards
Related Pathways
Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zanubrutinib-standard.html
Purity
99.90
Smiles
NC(C1=C2N(N=C1C3=CC=C(OC4=CC=CC=C4)C=C3)[C@H](C5CCN(C(C=C)=O)CC5)CCN2)=O
Molecular Formula
C27H29N5O3
Molecular Weight
471.55
Precautions
H301, H311, H331, H341
References & Citations
[1]Na Li, et al. Abstract 2597: BGB-3111 is a novel and highly selective Bruton's tyrosine kinase (BTK) inhibitor. Cancer Res 2015;75 (15 Suppl) :Abstract nr 2597.|[2]Guo Y, et al. Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase. J Med Chem. 2019 Sep 12;62 (17) :7923-7940.
Shipping Conditions
Room Temperature
Storage Conditions
4°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards
Clinical Information
Launched
Available Sizes
Frequently Asked Questions
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