K-975
K-975 is a potent, selective and orally active TEAD inhibitor, with a strong inhibitory effect against protein-protein interactions between YAP1/TAZ and TEAD. K-975 covalently binds to Cys359 located in the palmitate-binding pocket of TEAD via an acrylamide structure. K-975 exhibits antitumor activity on malignant pleural mesothelioma[1].
Product Specifications
CAS Number
2563855-03-6
UNSPSC
12352005
Target
YAP
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/k-975.html
Purity
99.89
Solubility
DMSO : 220 mg/mL (ultrasonic)
Smiles
C=CC(NC1=CC=C(C)C(OC2=CC=C(Cl)C=C2)=C1)=O
Molecular Formula
C16H14ClNO2
Molecular Weight
287.74
References & Citations
[1]Kaneda A, et, al. The novel potent TEAD inhibitor, K-975, inhibits YAP1/TAZ-TEAD protein-protein interactions and exerts an anti-tumor effect on malignant pleural mesothelioma. Am J Cancer Res. 2020 Dec 1;10 (12) :4399-4415.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
RC210159L1 10 µg
Beta crystallin S (CRYGS) (NM_017541) Human Tagged Lenti ORF Clone
Sign In for Pricing
View Details ![5H,6H,7H,8H,9H-Imidazo[1,2-a]azepine-3-carboxylic acid hydrochloride](https://cdn.genprice.uk/genprice/uk/genprice2.webp)
KHD03358-01 100 mg
5H,6H,7H,8H,9H-Imidazo[1,2-a]azepine-3-carboxylic acid hydrochloride
Sign In for Pricing
View Details KHD03358-02 1 g
5H,6H,7H,8H,9H-Imidazo[1,2-a]azepine-3-carboxylic acid hydrochloride
Sign In for Pricing
View Details