K-975

K-975 is a potent, selective and orally active TEAD inhibitor, with a strong inhibitory effect against protein-protein interactions between YAP1/TAZ and TEAD. K-975 covalently binds to Cys359 located in the palmitate-binding pocket of TEAD via an acrylamide structure. K-975 exhibits antitumor activity on malignant pleural mesothelioma[1].

Product Specifications

CAS Number

[2563855-03-6]

UNSPSC

12352005

Target

YAP

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/k-975.html

Purity

99.89

Solubility

DMSO : 220 mg/mL (ultrasonic)

Smiles

C=CC(NC1=CC=C(C)C(OC2=CC=C(Cl)C=C2)=C1)=O

Molecular Formula

C16H14ClNO2

Molecular Weight

287.74

References & Citations

[1]Kaneda A, et, al. The novel potent TEAD inhibitor, K-975, inhibits YAP1/TAZ-TEAD protein-protein interactions and exerts an anti-tumor effect on malignant pleural mesothelioma. Am J Cancer Res. 2020 Dec 1;10 (12) :4399-4415.