Urea-d4

Urea-d4 is the deuterium labeled Urea[1]. Urea is a powerful protein denaturant via both direct and indirect mechanisms[2]. A potent emollient and keratolytic agent[3]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[4]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.

Product Specifications

CAS Number

[1433-11-0]

Product Name Alternative

Carbonyl diamide-d4

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

Endogenous Metabolite

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Purity

99.95

Solubility

10 mM in DMSO|DMSO : 100mg/mL (ultrasonic) |H2O : 100mg/mL (ultrasonic)

Smiles

[2H]N([2H])C(N([2H])[2H])=O

Molecular Formula

CD4N2O

Molecular Weight

64.08

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Bennion BJ, et al. The molecular basis for the chemical denaturation of proteins by urea. Proc Natl Acad Sci U S A. 2003 Apr 29;100 (9) :5142-7.|[3]Pan M, et al. Urea: a comprehensive review of the clinical literature. Dermatol Online J. 2013 Nov 1519 (11) :20392.Wang H, et al. Urea. Subcell Biochem. 201473:7-29.|[4]Wang H, et al. Urea. Subcell Biochem. 201473:7-29.