Nociceptin (1-13), amide (TFA)
Nociceptin (1-13), amide TFA is a potent ORL1 receptor (opioid receptor-like 1 receptor, OP4) agonist with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain membranes[1][2].
Product Specifications
UNSPSC
12352209
Target
Opioid Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nociceptin-1-13-amide-tfa.html
Purity
99.87
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(C(F)(F)F)O.C[C@H]([C@@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CCCCN)=O)CCCNC(N)=N)=O)C)=O)CO)=O)CCCCN)=O)CCCNC(N)=N)=O)C)=O)=O)NC([C@@H](NC(CNC(CNC([C@H](CC1=CC=CC=C1)N)=O)=O)=O)CC2=CC=CC=C2)=O)O
Molecular Formula
C63H101F3N22O17
Molecular Weight
1495.61
References & Citations
[1]Varani K, et al. Nociceptin receptor binding in mouse forebrain membranes: thermodynamic characteristics and structure activity relationships. Br J Pharmacol. 1998 Dec;125 (7) :1485-90.|[2]Calo' G, et al. Pharmacology of nociceptin and its receptor: a novel therapeutic target. Br J Pharmacol. 2000 Apr;129 (7) :1261-83.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
NOP Receptor/ORL1
Available Sizes
Frequently Asked Questions
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