Nociceptin (1-13), amide (TFA)

Nociceptin (1-13), amide TFA is a potent ORL1 receptor (opioid receptor-like 1 receptor, OP4) agonist with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain membranes[1][2].

Product Specifications

UNSPSC

12352209

Target

Opioid Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nociceptin-1-13-amide-tfa.html

Purity

99.87

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(C(F)(F)F)O.C[C@H]([C@@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CCCCN)=O)CCCNC(N)=N)=O)C)=O)CO)=O)CCCCN)=O)CCCNC(N)=N)=O)C)=O)=O)NC([C@@H](NC(CNC(CNC([C@H](CC1=CC=CC=C1)N)=O)=O)=O)CC2=CC=CC=C2)=O)O

Molecular Formula

C63H101F3N22O17

Molecular Weight

1495.61

References & Citations

[1]Varani K, et al. Nociceptin receptor binding in mouse forebrain membranes: thermodynamic characteristics and structure activity relationships. Br J Pharmacol. 1998 Dec;125 (7) :1485-90.|[2]Calo' G, et al. Pharmacology of nociceptin and its receptor: a novel therapeutic target. Br J Pharmacol. 2000 Apr;129 (7) :1261-83.