Deoxycorticosterone

Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as an aldosterone precursor. Deoxycorticosterone is an agonist for O. mykiss mineralocorticoid receptor (rtMR) transcription with EC50 of 0.16 nM[3]. Deoxycorticosterone could acts as an immune stimulator in fish[4].

Product Specifications

CAS Number

[64-85-7]

UNSPSC

12352211

Hazard Statement

H351, H373

Target

Endogenous Metabolite; Mineralocorticoid Receptor

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Inflammation/Immunology; Others

Assay Protocol

https://www.medchemexpress.com/Deoxycorticosterone.html

Purity

99.78

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@@H](C(CO)=O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC2)=O

Molecular Formula

C21H30O3

Molecular Weight

330.46

Precautions

H351, H373

References & Citations

[1]KAGAWA CM, et al. Action of new steroids in blocking effects of aldosterone and desoxycorticosterone on salt. Science. 1957 Nov 15;126 (3281) :1015-6.|[2]Milla S, et al., Plasma 11-deoxycorticosterone (DOC) and mineralocorticoid receptor testicular expression during rainbow trout Oncorhynchus mykiss spermiation: implication with 17alpha, 20beta-dihydroxyprogesterone on the milt fluidity? Reprod Biol Endocrinol. 2008 May 19;6:19.|[3]Sturm A, et al., 11-deoxycorticosterone is a potent agonist of the rainbow trout (Oncorhynchus mykiss) mineralocorticoid receptor. Endocrinology. 2005 Jan;146 (1) :47-55.|[4]Mathieu C, et al., First evidence of the possible implication of the 11-deoxycorticosterone (DOC) in immune activity of Eurasian perch (Perca fluviatilis, L.) : comparison with cortisol. Comp Biochem Physiol A Mol Integr Physiol. 2013 Jun;165 (2) :149-58.