Choline-13C2 (chloride)

Choline-13C2 (chloride) is the 13C labeled Choline chloride[1]. Choline chloride is an essential nutrient that activates alpha7 nicotinic receptors and has analgesic and anti-inflammatory activity. Glycerophosphoinositol choline can affect diseases such as liver disease, atherosclerosis and neurological disorders[2][3].

Product Specifications

CAS Number

[202190-49-6]

UNSPSC

12352211

Hazard Statement

H315, H319

Target

Endogenous Metabolite; nAChR

Type

Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/choline-13c2-chloride.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

C[N+](C)(C)[13CH2][13CH2]O.[Cl-]

Molecular Formula

C3 13C2H14ClNO

Molecular Weight

141.61

Precautions

H315, H319

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]M Q Holmes-McNary, et al. Apoptosis is induced by choline deficiency in fetal brain and in PC12 cells. Brain Res Dev Brain Res. 1997 Jul 18;101 (1-2) :9-16.|[3]T J Rowley, et al. Antinociceptive and anti-inflammatory effects of choline in a mouse model of postoperative pain. Br J Anaesth. 2010 Aug105 (2) :201-7.