Propyl pyrazole triol

Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%) [1][2].

Product Specifications

CAS Number

[263717-53-9]

Product Name Alternative

PPT

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ppt.html

Purity

99.11

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CCCC1=C(C2=CC=C(O)C=C2)N(C3=CC=C(O)C=C3)N=C1C4=CC=C(O)C=C4

Molecular Formula

C24H22N2O3

Molecular Weight

386.44

Precautions

H315, H319, H335

References & Citations

[1]Influence of cellular ERalpha/ERbeta ratio on the ERalpha-agonist induced proliferation of human T47D breast cancer cells.|[2]Stauffer SR, et al. Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists. J Med Chem. 2000 Dec 28;43 (26) :4934-47.