IL-20R beta, Cynomolgus (HEK293, His)

IL-20R beta Protein (IL20RB) is the beta subunit of IL-20 receptor, forms functional heterodimers with different subunit protein and involves in STAT3 activation pathway[1]. The IL-20RA/IL-20RB dimer is a receptor for IL-19, IL-20 and IL-24. The IL-22RA1/IL-20RB dimer is a receptor for IL-20 and IL-24[2]. IL-20R beta Protein is consists of 308 amino acids (M1-S311) with a transmembrane domain (230-254 a.a.). IL-20R beta Protein, Cynomolgus (HEK293, Fc) is fibronectin type-III domain-containing protein, produced in HEK293 cells with a C-Terminal Fc-tag.

DEVAILPAPQ NLSVLSTNMK HLLMWSPVTV PGETVYYSVE YQGEYESLYT SHIWIPSSWC SLTEGPECDV TDDITATVPY NLRVRATLGS QTSAWSILKH PFNRNSTILT PPGMEITKDG FHLVIELEDL GPQFEFLVAY WRREPGAEEH VKMVRSGGIP VHLETMEPGA AYCVKAQTFV KAIGRYSAFS QTECVEVQGE A

[1]Blumberg H, et al. Interleukin 20: discovery, receptor identification, and role in epidermal function. Cell. 2001 Jan 12;10 4(1):9-19.|[2]Wegenka UM. IL-20: biological functions mediated through two types of receptor complexes. Cytokine Growth Factor Rev. 2010 Oct;21(5):353-63.|[3]Sheikh F, et al. Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2. J Immunol. 2004 Feb 15;172(4):2006-10.|[4]Wang M, et al. Interleukin-24 and its receptors. Immunology. 2005 Feb;114(2):166-70.