BPKDi

BPKDi is an inhibitor of PKD. BPKDi inhibits three members of the PKD family, PKD1, PKD2, and PKD3, with IC50 values of 1 nM, 9 nM, and 1 nM, respectively. BPKDi blocks signal-dependent phosphorylation and nuclear export of class IIa HDACs in cardiomyocytes and concomitantly suppresses hypertrophy of these cells[1].

Product Specifications

CAS Number

[1201673-28-0]

Product Name Alternative

d,l-SKF89976A hydrochloride

UNSPSC

12352005

Target

HDAC; PKD

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Neuroscience-Neurodegeneration

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/bpkdi.html

Purity

99.60

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(N)C1=CC(C2=CC(NC3CCCCC3)=NC=C2)=NC(N4CCNCC4)=C1

Molecular Formula

C21H28N6O

Molecular Weight

380.49

References & Citations

[1]Lauren Monovich, et al. A novel kinase inhibitor establishes a predominant role for protein kinase D as a cardiac class IIa histone deacetylase kinase. FEBS Lett. 2010 Feb 5;584 (3) :631-7.