Hydrocortisone hemisuccinate (Standard)

Hydrocortisone hemisuccinate (Standard) is the analytical standard of Hydrocortisone hemisuccinate. This product is intended for research and analytical applications. Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate), a physiological glucocorticoid, is an orally active steroidal anti-in ammatory agent (SAID) . Hydrocortisone hemisuccinate inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone hemisuccinate can be used for the research of ulcerative colitis (UC) .

Product Specifications

CAS Number

[2203-97-6]

Product Name Alternative

Hydrocortisone 21-hemisuccinate (Standard)

UNSPSC

12352211

Target

Glucocorticoid Receptor; Interleukin Related; Reference Standards

Type

Reference Standards

Related Pathways

Immunology/Inflammation; Others; Vitamin D Related/Nuclear Receptor

Field of Research

Endocrinology; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hydrocortisone-hemisuccinate-standard.html

Purity

99.67

Smiles

C[C@@]12[C@](C(COC(CCC(O)=O)=O)=O)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O

Molecular Formula

C25H34O8

Molecular Weight

462.53

References & Citations

[1]Kang BS, et, al. Inhibitory effects of anti-inflammatory drugs on interleukin-6 bioactivity. Biol Pharm Bull. 2001 Jun;24 (6) :701-3.|[2]You YC, et, al. In vitro and in vivo application of pH-sensitive colon-targeting polysaccharide hydrogel used for ulcerative colitis therapy. Carbohydr Polym. 2015 Oct 5;130:243-53.|[3]Langhoff E, et, al. The immunosuppressive potency in vitro of physiological and synthetic steroids on lymphocyte cultures. Int J Immunopharmacol. 1987;9 (4) :469-73.