Hydrocortisone hemisuccinate (Standard)
Product Specifications
UNSPSC Description
Hydrocortisone hemisuccinate (Standard) is the analytical standard of Hydrocortisone hemisuccinate. This product is intended for research and analytical applications. Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate), a physiological glucocorticoid, is an orally active steroidal anti-in ammatory agent (SAID). Hydrocortisone hemisuccinate inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone hemisuccinate can be used for the research of ulcerative colitis (UC).
Target Antigen
Glucocorticoid Receptor; Interleukin Related
Type
Reference Standards
Related Pathways
Immunology/Inflammation;Vitamin D Related/Nuclear Receptor
Field of Research
Endocrinology; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hydrocortisone-hemisuccinate-standard.html
Smiles
C[C@@]12[C@](C(COC(CCC(O)=O)=O)=O)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O
Molecular Weight
462.53
References & Citations
[1]Kang BS, et, al. Inhibitory effects of anti-inflammatory drugs on interleukin-6 bioactivity. Biol Pharm Bull. 2001 Jun;24(6):701-3.|[2]You YC, et, al. In vitro and in vivo application of pH-sensitive colon-targeting polysaccharide hydrogel used for ulcerative colitis therapy. Carbohydr Polym. 2015 Oct 5;130:243-53.|[3]Langhoff E, et, al. The immunosuppressive potency in vitro of physiological and synthetic steroids on lymphocyte cultures. Int J Immunopharmacol. 1987;9(4):469-73.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-B1402R/Hydrocortisone-hemisuccinate-Standard-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B1402R/
Clinical Information
Launched
CAS Number
2203-97-6
Available Sizes
Curated Selection
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