4-Methylumbelliferyl phosphate (disodium)

4-Methylumbelliferyl phosphate (4-MUP) disodium, an anionic organophosphate, is a acid and alkaline phosphatase fluorogenic substrate. 4-Methylumbelliferyl phosphate disodium is also a nerve agent simulant[1][2][3].

Product Specifications

CAS Number

[22919-26-2]

Product Name Alternative

4-MUP (disodium) ; MUP (disodium)

UNSPSC

12171500

Hazard Statement

H302-H315-H319-H335

Target

Phosphatase

Type

Dye Reagents

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/4-methylumbelliferyl-phosphate-disodium.html

Solubility

10 mM in DMSO

Smiles

O=C1C=C(C)C2=CC=C(OP(O[Na])(O[Na])=O)C=C2O1

Molecular Formula

C10H7Na2O6P

Molecular Weight

300.11

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Chambers JP, et al. Determination of serum acid phosphatase in Gaucher's disease using 4-methylumbelliferyl phosphate. Clin Chim Acta. 1977 Oct 1;80 (1) :67-77.|[2]Watanabe F, et al. The analysis of alkaline phosphatase isoenzyme using 4-methylumbelliferyl phosphate as substrate on a cellulose acetate membrane. Clin Chim Acta. 1979 Feb 1;91 (3) :273-6.|[3]Hao Chen, et al. Autonomic Molecular Transport for Ultrasensitive Surface-Enhanced Infrared Absorption Spectroscopy. ACS Appl. Polym. Mater. 2020, 2, 9, 3929-3935