LY43578

LY43578 is an orally active aromatase inhibitor. LY43578 inhibits P-450-dependent p-nitroanisole O-demethylation and ethylmorphine N-demethylation in hepatic microsomes isolated from rat, with the IC50 of 0.3 and 5 μΜ, respectively. LY43578 can be used for neurological disorder study[1][2].

Product Specifications

CAS Number

[26766-35-8]

UNSPSC

12352005

Target

Cytochrome P450; Monoamine Oxidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ly43578.html

Purity

99.76

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC(C1=CC=C(C=C1)Cl)(C2=CN=CN=C2)C3=CC=C(C=C3)Cl

Molecular Formula

C17H12Cl2N2O

Molecular Weight

331.20

References & Citations

[1]Lindstrom TD, et al. Disposition of the aromatase inhibitor LY56110 and associated induction and inhibition studies in rats, dogs, and monkeys. Fundam Appl Toxicol. 1987;8 (4) :595-604.|[2]Gonzalez MI, et al. Injection of an aromatase inhibitor after the critical period of sexual differentiation. Pharmacol Biochem Behav. 1994;47 (1) :183-186.