Human GRO alpha/CXCL1 (Recombinant)

<strong>Human GRO alpha/CXCL1</strong>_x000D_ <strong>Catalog number:</strong> B2010365_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Volume/Weight:</strong> 10 ug_x000D_ <strong>pH:</strong> 7.4 upon reconstitution_x000D_ <strong>Supplied as:</strong> Lyophilized Powder_x000D_ <strong>Appearance:</strong> Powder_x000D_ <strong>Applications:</strong> highly pure Human GRO alpha/CXCL1 expressed in E. coli. This protein acts as a protein with putative roles in inflammation, angiogenesis, tumorigenesis, and wound healing._x000D_ <strong>Storage:</strong> -20C_x000D_ <strong>Keywords:</strong> HuGRO-α/CXCL1; NAP-3; MGSA; Growth-regulated alpha protein_x000D_ <strong>Grade:</strong> Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Lo HM, Lai TH, Li CH, Wu WB. TNF-α induces CXCL1 chemokine expression and_x000D_ release in human vascular endothelial cells in vitro via two distinct signaling_x000D_ pathways. Acta Pharmacol Sin. 2014 Mar;35(3):339-50._x000D_ _x000D_ 2: Kanda Y, Koike K, Sakamoto Y, Osako Y, Masuhara K, Watanabe K, Tsurufuji S,_x000D_ Hirota K, Miyake A. GRO-alpha in human serum: differences related to age and_x000D_ sex. Am J Reprod Immunol. 1997 Jul;38(1):33-8._x000D_ _x000D_ 3: Filipovic R, Jakovcevski I, Zecevic N. GRO-alpha and CXCR2 in the human fetal_x000D_ brain and multiple sclerosis lesions. Dev Neurosci. 2003 Mar-Aug;25(2-4):279-90._x000D_ _x000D_ 4: Losy J, Zaremba J, Skrobański P. CXCL1 (GRO-alpha) chemokine in acute_x000D_ ischaemic stroke patients. Folia Neuropathol. 2005;43(2):97-102._x000D_ _x000D_ 5: Yung MM, Tang HW, Cai PC, Leung TH, Ngu SF, Chan KK, Xu D, Yang H, Ngan HY,_x000D_ Chan DW. GRO-α and IL-8 enhance ovarian cancer metastatic potential via the_x000D_ CXCR2-mediated TAK1/NFκB signaling cascade. Theranostics. 2018 Feb_x000D_ 2;8(5):1270-1285._x000D_ _x000D_ 6: Zhou Y, Zhang J, Liu Q, Bell R, Muruve DA, Forsyth P, Arcellana-Panlilio M,_x000D_ Robbins S, Yong VW. The chemokine GRO-alpha (CXCL1) confers increased_x000D_ tumorigenicity to glioma cells. Carcinogenesis. 2005 Dec;26(12):2058-68._x000D_ _x000D_ 7: Fanelli G, Benedetti F, Wang SM, Lee SJ, Jun TY, Masand PS, Patkar AA, Han C,_x000D_ Serretti A, Pae CU, Fabbri C. Reduced CXCL1/GRO chemokine plasma levels are a_x000D_ possible biomarker of elderly depression. J Affect Disord. 2019 Apr_x000D_ 15;249:410-417._x000D_ _x000D_ 8: Lisi S, Sisto M, Lofrumento DD, D'Amore M, De Lucro R, Ribatti D. GRO-α/CXCR2_x000D_ system and ADAM17 correlated expression in Sjögren's syndrome. Inflammation._x000D_ 2013 Jun;36(3):759-66._x000D_ _x000D_ 9: Geiser T, Dewald B, Ehrengruber MU, Clark-Lewis I, Baggiolini M. The_x000D_ interleukin-8-related chemotactic cytokines GRO alpha, GRO beta, and GRO gamma_x000D_ activate human neutrophil and basophil leukocytes. J Biol Chem. 1993 Jul_x000D_ 25;268(21):15419-24._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/31759853/">10: Kuo CH, Lee MS, Kuo HF, Lin YC, Hung CH. Azithromycin suppresses Th1- and_x000D_ Th2-related chemokines IP-10/MDC in human monocytic cell line. J Microbiol_x000D_ Immunol Infect. 2019 Dec;52(6):872-879. </a>_x000D_ _x000D_ <strong>Products Related to Human GRO alpha/CXCL1 </strong> <a href="https://moleculardepot.com/product-category/Proteins/">: Proteins</a>