HIV-1 integrase inhibitor 12
HIV-1 integrase inhibitor 12 (Compound 17) is an inhibitor for HIV-1 integrase with an IC50 of 1.4 nM. HIV-1 integrase inhibitor 12 inhibits the HIV-1 WT and HIV-1 T125A, with IC50 of 7.4 and 120 nM, respectively. HIV-1 integrase inhibitor 12 exhibits metabolic stability and Caco-2 permeability, and good pharmacokinetic characteristics with good bioavailability (64%) and low clearance (0.16 L/hr/kg) in rats[1].
Product Specifications
UNSPSC
12352005
Target
HIV Integrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/hiv-1-integrase-inhibitor-12.html
Smiles
CC1=CC(C(NC2CCCCC2)=O)=C(C3=C1[C@@H](C(O)=O)OC(C)(C)C)CC[C@]43CC[C@H](C)CC4
Molecular Formula
C29H43NO4
Molecular Weight
469.66
References & Citations
[1]Adachi K, et al., Design and synthesis of novel and potent allosteric HIV-1 integrase inhibitors with a spirocyclic moiety. Bioorg Med Chem Lett. 2024 Jun 26;110:129864.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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