GL0388
GL0388 is a Bax activator that results in Bax insertion into mitochondrial membrane. GL0388 shows antiproliferative activities against various cancer cells, with IC50s of 0.299-1.57 μM. GL0388 activates Bax and induce Bax-mediated apoptosis. GL0388 suppresses breast cancer xenograft tumor growth in vivo[1].
Product Specifications
CAS Number
[2886772-68-3]
UNSPSC
12352005
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gl0388.html
Purity
98.01
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NCCOC1=NC=CC=C1/C=C2C3=C(C4=C\2C=C(C=C4)F)C=CC=C3
Molecular Formula
C21H17FN2O
Molecular Weight
332.37
References & Citations
[1]Liu G, et, al. Further lead optimization on Bax activators: Design, synthesis and pharmacological evaluation of 2-fluoro-fluorene derivatives for the treatment of breast cancer. Eur J Med Chem. 2021 Jul 5;219:113427.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bax
Available Sizes
Curated Selection
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