Nudol
Nudol is a phenanthrene compound that has anti-cancer activity. Nudol inhibits cell proliferation, induces cell apoptosis. Nudol inhibits MMP-2M and MMP-9 activity (Ki: 988.9 nM, 1.76 μM, respectively) . Nudol can be used in the research of cancers, such as osteosarcoma[1][2].
Product Specifications
CAS Number
86630-46-8
UNSPSC
12352005
Target
Apoptosis; MMP
Type
Natural Products
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nudol.html
Solubility
10 mM in DMSO
Smiles
OC1=C(OC)C(OC)=C2C3=CC=C(O)C=C3C=CC2=C1
Molecular Formula
C16H14O4
Molecular Weight
270.28
References & Citations
[1]Yuying Zhang, et al. Nudol, a phenanthrene derivative from Dendrobium nobile, induces cell cycle arrest and apoptosis and inhibits migration in osteosarcoma cells. Drug Des Devel Ther. 2019 Jul 29;13:2591-2601. |[2]Mohammad Al-Amin, et al. Inhibitory Effect of Dioscorea bulbifera Tubers on the Migration of Triple-Negative Breast Cancer Cells. Breast Cancer Cells. Rev. Bras. Farmacogn. 31, 335–341 (2021) .
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
MMP-2; MMP-9
Available Sizes
Frequently Asked Questions
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