Duocarmycin GA
Duocarmycin GA is an antibody agent conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin GA can be used against multi-agent resistant cell lines.
Product Specifications
CAS Number
[1613286-59-1]
UNSPSC
12352203
Target
ADC Payload; DNA Alkylator/Crosslinker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/duocarmycin-ga.html
Purity
99.78
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC2=C(C=C1)C=C(C(N3C[C@@H](CCl)C4=C3C=C(O)C5=CC=CC=C45)=O)N2)CN(C)C
Molecular Formula
C26H25ClN4O3
Molecular Weight
476.95
References & Citations
[1]Searcey M. Duocarmycins--natures prodrugs? Curr Pharm Des. 2002;8 (15) :1375-89.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Duocarmycins
Available Sizes
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