BC-23
BC-23 (NSC 45382) is a proteasome inhibitor. BC-23 exhibits good inhibition of CT-L activity of the proteasome and is selective for malignant over normal cells[1][2].
Product Specifications
CAS Number
6298-15-3
Product Name Alternative
NSC 45382
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Proteasome
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bc-23.html
Purity
97.37
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=S(C1=CC=C(C=C1)NC(C2=O)=C(C(C3=C2C=CC=C3)=O)Cl)(NC4=NC=CC=C4)=O
Molecular Formula
C21H14ClN3O4S
Molecular Weight
439.87
Precautions
H302, H315, H319, H335
References & Citations
[1]Lawrence HR, et, al. Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors. Bioorg Med Chem. 2010 Aug 1;18 (15) :5576-92.|[2]Zhang Q, et, al. Enhancement of Radiation Sensitivity in Lung Cancer Cells by a Novel Small Molecule Inhibitor That Targets the β-Catenin/Tcf4 Interaction. PLoS One. 2016 Mar 25;11 (3) :e0152407.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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