HEC1 Recombinant Rabbit Monoclonal Antibody [JE31-10]
Kinetochore protein NDC80 homolog is a protein that in humans is encoded by the NDC80 gene. Ndc80 is one of the proteins of outer kinetochore. It forms a heterotetramer with proteins NUF2, SPC25, and SPC24. This protein complex has microtubule-binding domains. HEC is one of several proteins involved in spindle checkpoint signaling. This surveillance mechanism assures correct segregation of chromosomes during cell division by detecting unaligned chromosomes and causing prometaphase arrest until the proper bipolar attachment of chromosomes is achieved. NDC80 has been shown to interact with MIS12, NEK2 and PSMC2.v
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
NDC80, HEC, HEC1, KNTC2
Swiss Prot
O14777 Human
Cellular Locus
Nucleus, Chromosome, centromere, kinetochore.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within Human HEC1 aa 593-642 / 642.
Isotype
IgG
Clone
JE31-10
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB
Positive Control
Concentration
1 mg/mL
Dilution
WB: 1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 74 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
Frequently Asked Questions
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