AR-R17779 (hydrochloride)

AR-R17779 hydrochloride is a potent and selective full agonist of nAChR, with Kis of 92 and 16000 nM for α7 and α4β2 subtype, respectively. AR-R17779 hydrochloride can improve learning and memory in rats. AR-R17779 hydrochloride also has anxiolytic activity. AR-R17779 hydrochloride can reduce inflammation by activating antiinflammatory cholinergic (vagal) pathways[1][2][4].

Product Specifications

CAS Number

[178419-42-6]

UNSPSC

12352005

Hazard Statement

H315, H318, H335

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ar-r17779-hydrochloride.html

Purity

99.0

Solubility

H2O : 32 mg/mL (ultrasonic)

Smiles

O=C(NC1)O[C@@]21CN3CCC2CC3.[H]Cl

Molecular Formula

C9H15ClN2O2

Molecular Weight

218.68

Precautions

H315, H318, H335

References & Citations

[1]Mullen G, et, al. (-) -Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the alpha 7 nicotinic acetylcholine receptor. J Med Chem. 2000 Nov 2;43 (22) :4045-50.|[2]Levin ED, et, al. AR-R17779, and alpha7 nicotinic agonist, improves learning and memory in rats. Behav Pharmacol. 1999 Nov;10 (6-7) :675-80.|[3]Maanen MA, et, al. Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice. Arthritis Rheum. 2009 Jan;60 (1) :114-22.|[4]Lopes F, et, al. Involvement of Mast Cells in α7 Nicotinic Receptor Agonist Exacerbation of Freund's Complete Adjuvant-Induced Monoarthritis in Mice.