2’-O-Methyl-5’-O-DMTr-5-iodouridine
2’-O-Methyl-5’-O-DMTr-5-iodouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Product Specifications
CAS Number
[588691-24-1]
Product Name Alternative
5'-O-[Bis (4-methoxyphenyl) phenylmethyl]-5-iodo-2'-O-methyl-uridine
UNSPSC
12352005
Hazard Statement
H302
Target
Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/2-o-methyl-5-o-dmtr-5-iodouridine.html
Solubility
10 mM in DMSO
Smiles
COC(C=C1)=CC=C1C(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)OC[C@@H]4[C@@H](O)[C@@H](OC)[C@H](N5C(NC(C(I)=C5)=O)=O)O4
Molecular Formula
C31H31IN2O8
Molecular Weight
686.49
Precautions
P264-P270-P330-P501
References & Citations
[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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