ORM-10103

ORM-10103 is a specific inhibitor of the Na+/Ca2+ exchanger (NCX), which decreases the NCX current with estimated IC50s of 55 and 67 nM at -80 and at 20 mV, respectively[1][2].

Product Specifications

CAS Number

[488847-28-5]

UNSPSC

12352005

Hazard Statement

H301, H413

Target

Na+/Ca2+ Exchanger

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/orm-10103.html

Concentration

10mM

Purity

99.43

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=[N+](C1=CN=C(OC2=CC=C3C(CCC(C4=CC=CC=C4)O3)=C2)C=C1)[O-]

Molecular Formula

C20H16N2O4

Molecular Weight

348.35

Precautions

H301, H413

References & Citations

[1]Jost N, et al. ORM-10103, a novel specific inhibitor of the Na+/Ca2+ exchanger, decreases early and delayed afterdepolarizations in the canine heart. Br J Pharmacol. 2013 Oct;170 (4) :768-78.|[2]Kohajda Z, et al. The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments. PLoS One. 2016 Nov 10;11 (11) :e0166041.