NP213 (TFA)

NP213 TFA is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 TFA targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 TFA is effective and well-tolerated in resolving nail fungal infections[1][2].

Product Specifications

UNSPSC

12352209

Hazard Statement

H302, H315, H319

Target

Fungal

Type

Peptides

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/np213-tfa.html

Purity

99.80

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

N=C(N)NCCC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](N1)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)C(N[C@H](C(N[C@H](C(N[C@H](C1=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O.O=C(O)C(F)(F)F

Molecular Formula

C44H85F3N28O9

Molecular Weight

1207.32

Precautions

H302, H315, H319

References & Citations

[1]Mercer DK, et al. Improved Methods for Assessing Therapeutic Potential of Antifungal Agents against Dermatophytes and Their Application in the Development of NP213, a Novel Onychomycosis Therapy Candidate.Antimicrob Agents Chemother. 2019 Apr 25;63 (5) . pii: e02117-18.|[2]Neelabh, et al. Sequential and Structural Aspects of Antifungal Peptides from Animals, Bacteria and Fungi Based on Bioinformatics Tools.Probiotics Antimicrob Proteins. 2016 Jun;8 (2) :85-101.|[3]Novamycin®/NP339 Technology Summary