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15 (R) -PTA2

15 (R) -PTA2 (15 (R) -Pinanethromboxane A2) is an antithrombotic agent that inhibits platelet aggregation. 15 (R) -PTA2 inhibits stable prostaglandin endoperoxide analog-induced constriction of feline coronary arteries and stabilizes hepatic lysosomes. 15 (R) -PTA2 also inhibits thromboxane synthase but has no effect on prostacyclin synthase[1].

Product Specifications

CAS Number

71154-83-1

Product Name Alternative

15 (R) -Pinanethromboxane A2

UNSPSC

12352211

Hazard Statement

H225-H319

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/15-r-pta2.html

Solubility

10 mM in DMSO

Smiles

OC(CCC/C=C\C[C@H]1[C@@]2([H])C(C)([C@](C[C@@H]1/C=C/[C@H](O)CCCCC)([H])C2)C)=O

Molecular Formula

C24H40O3

Molecular Weight

376.57

Precautions

P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P370+P378-P403+P235-P501

References & Citations

[1]Nicolaou KC, et al. Synthesis and biological properties of pinane-thromboxane A2, a selective inhibitor of coronary artery constriction, platelet aggregation, and thromboxane formation. Proc Natl Acad Sci U S A. 1979 Jun;76 (6) :2566-70.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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