Laduviglusib (trihydrochloride)
Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib trihydrochloride is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib trihydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib trihydrochloride induces autophagy[1][2][3].
Product Specifications
CAS Number
[1782235-14-6]
Product Name Alternative
CHIR-99021 (trihydrochloride) ; CT99021 trihydrochloride
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; GSK-3; Organoid; Wnt; β-catenin
Type
Reference compound
Related Pathways
Autophagy; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/laduviglusib-trihydrochloride.html
Purity
99.11
Solubility
DMSO : 250 mg/mL (ultrasonic) |H2O : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N#CC1=CC=C(NCCNC2=NC=C(C3=NC=C(C)N3)C(C4=CC=C(Cl)C=C4Cl)=N2)N=C1.[H]Cl.[H]Cl.[H]Cl
Molecular Formula
C22H21Cl5N8
Molecular Weight
574.72
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GSK-3α; GSK-3β
Citation 01
Available Sizes
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