ML-298
Product Specifications
Product Name Alternative
WYE-125132
UNSPSC Description
ML298 is a potent and selective inhibitor of Phospholipase D2 (PLD2) with an IC50 of 355 nM. ML298 decreases invasive migration in U87-MG glioblastoma cells[1].
Target Antigen
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ml-298.html
Purity
98.0
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
FC1=CC=C(C=C1F)C(NCCN2CCC3(CC2)C(NCN3C4=CC(F)=CC=C4)=O)=O
Molecular Weight
432.44
References & Citations
[1]O'Reilly MC, et al. Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-Triazaspiro[4.5]decane Core: discovery of Ml298 and Ml299 that decrease invasive migration in U87-MG glioblastoma cells. J Med Chem. 2013 Mar 28;56(6):2695-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-116165/ML-298-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-116165/ML-298-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1426916-02-0
Available Sizes
Curated Selection
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