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7-Acetoxy-4-methylcoumarin

7-Acetoxy-4-methylcoumarin is an inhibitor of GST.7-Acetoxy-4-methylcoumarin inhibits AFB1-DNA binding in vitro with 36.7% inhibition[1][2].

Product Specifications

CAS Number

2747-05-9

Product Name Alternative

4-Methylumbelliferyl acetate

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Glutathione S-transferase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/7-acetoxy-4-methylcoumarin.html

Purity

98.65

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C1C=C(C)C2=CC=C(OC(C)=O)C=C2O1

Molecular Formula

C12H10O4

Molecular Weight

218.21

Precautions

H315, H319, H335

References & Citations

[1]Feuer, G, et al. Induction of drug-metabolizing enzymes of rat liver by derivatives of coumarin. Canadian Journal of Physiology and Pharmacology, 48 (4), 232–240.|[2]Raj HG, et al. Mechanism of biochemical action of substituted benzopyran-2-ones. Part 8: Acetoxycoumarin: protein transacetylase specificity for aromatic nuclear acetoxy groups in proximity to the oxygen heteroatom. Bioorg Med Chem. 2001 May;9 (5) :1085-9.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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