Human CD70 Protein

<strong>Human CD70 Protein</strong>_x000D_ <strong>Catalog number:</strong> B2011888_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 1 mg/mL_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20 °C_x000D_ <strong>Keywords:</strong> CD70 antigen protein, CD70L protein, CD70LG protein, TNFSF7 protein_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Wajant H. Therapeutic targeting of CD70 and CD27 Expert Opin Ther Targets. 2016 Aug;20(8):959-73._x000D_ 2: Sauer T, Parikh K, Sharma S, Omer B, Sedloev D, Chen Q, Angenendt L, Schliemann C, Schmitt M, Müller-Tidow C, Gottschalk S, Rooney CM. CD70-specific CAR T cells have potent activity against acute myeloid leukemia without HSC toxicity Blood. 2021 Jul 29;138(4):318-330._x000D_ 3: Jin L, Ge H, Long Y, Yang C, Chang YE, Mu L, Sayour EJ, De Leon G, Wang QJ, Yang JC, Kubilis PS, Bao H, Xia S, Lu D, Kong Y, Hu L, Shang Y, Jiang C, Nie J, Li S, Gu Y, Sun J, Mitchell DA, Lin Z, Huang J. CD70, a novel target of CAR T-cell therapy for gliomas Neuro Oncol. 2018 Jan 10;20(1):55-65._x000D_ 4: Jacobs J, Deschoolmeester V, Zwaenepoel K, Rolfo C, Silence K, Rottey S, Lardon F, Smits E, Pauwels P. CD70: An emerging target in cancer immunotherapy Pharmacol Ther. 2015 Nov;155:1-10._x000D_ 5: Zhang Y, Zheng J. Functions of Immune Checkpoint Molecules Beyond Immune Evasion Adv Exp Med Biol. 2020;1248:201-226._x000D_ 6: Ravell JC, Chauvin SD, He T, Lenardo M. An Update on XMEN Disease J Clin Immunol. 2020 Jul;40(5):671-681._x000D_ 7: Starzer AM, Berghoff AS. New emerging targets in cancer immunotherapy: CD27 (TNFRSF7) ESMO Open. 2020 Mar;4(Suppl 3):e000629._x000D_ 8: Yang M, Tang X, Zhang Z, Gu L, Wei H, Zhao S, Zhong K, Mu M, Huang C, Jiang C, Xu J, Guo G, Zhou L, Tong A. Tandem CAR-T cells targeting CD70 and B7-H3 exhibit potent preclinical activity against multiple solid tumors Theranostics. 2020 Jun 18;10(17):7622-7634._x000D_ 9: Choi IK, Wang Z, Ke Q, Hong M, Paul DW Jr, Fernandes SM, Hu Z, Stevens J, Guleria I, Kim HJ, Cantor H, Wucherpfennig KW, Brown JR, Ritz J, Zhang B. Mechanism of EBV inducing anti-tumour immunity and its therapeutic use Nature. 2021 Feb;590(7844):157-162._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/31186046">10: Wang H, Kaur G, Sankin AI, Chen F, Guan F, Zang X. Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies J Hematol Oncol. 2019 Jun 11;12(1):59. </a>_x000D_ _x000D_ <strong>Products Related to Human CD70 Protein can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>