Antitumor agent-153
Antitumor agent-153 (compound 11b) is an optimized H2A histone ubiquitination inhibitor based on PRT4165. Antitumor agent-153 inhibits the viability of human osteosarcoma U2OS cells and reduces histone H2A monoubiquitination, exhibiting anticancer activity[1].
Product Specifications
CAS Number
9007-83-4
UNSPSC
12352005
Target
E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-153.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(C/2=O)C=CC=C1)C2=C/C3=C([N+]([O-])=O)C=CC=C3[N+]([O-])=O
Molecular Formula
C16H8N2O6
Molecular Weight
324.24
References & Citations
[1]Ni S, et al. Identification of a novel histone H2A mono-ubiquitination-inhibiting cell-active small molecule. Bioorg Med Chem Lett. 2024 Jun 1;105:129759.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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