Firazorexton

Firazorexton (TAK-994 free base) is an orally active and brain-penetrant orexin type 2 receptor (OX2R) selective agonist. Firazorexton (TAK-994 free base) can promote wakefulness and has the potential to improve narcolepsy-like symptoms in mice[1].

Product Specifications

CAS Number

[2274802-95-6]

Product Name Alternative

TAK-994 (free base)

UNSPSC

12352005

Target

ERK; Orexin Receptor (OX Receptor)

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; Neuronal Signaling; Stem Cell/Wnt

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/firazorexton.html

Concentration

10mM

Purity

99.94

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C(N(CC1)[C@H]([C@H]1N[S](C)(=O)=O)CC(C=CC=C2C3=CC(F)=CC(F)=C3)=C2F)C(C)(O)C

Molecular Formula

C22H25F3N2O4S

Molecular Weight

470.51

References & Citations

[1]Ishikawa T, et al. TAK-994, a Novel Orally Available Brain-Penetrant Orexin 2 Receptor-Selective Agonist, Suppresses Fragmentation of Wakefulness and Cataplexy-Like Episodes in Mouse Models of Narcolepsy. J Pharmacol Exp Ther. 2023 Jun;385 (3) :193-204.